We went to Rome for four nights beginning on December 31, 2009. It was one of the best vacations I have ever taken.
As you can tell from the ground in this picture, Rome was a bit rainy at times, and it was chilly. It meant, though, that there weren't huge crowds.
This is the Basilica di Santa Maria Maggiore, near our hotel in the center of Rome, near the main train station. We saw this on our first morning in Rome. Not a bad way to start the vacation!